New research is being undertaken to help discover the link between insulin-like molecules and how they bind to receptors. This study could provide ground-breaking evidence which could help revolutionise the treatment for diabetic patients. The Curtin University School of Biomedical Sciences are currently in the process of researching this subject in the hope of defining the molecular nature of this insulin action. The study being undertaken will explore the interaction through an artificial system which hopefully will reveal a new form of treatment to improve the lives of those suffering with diabetes.
Often, those living with diabetes are met with a problem at one stage or another with the level of activation of the insulin receptor, or with the activation of molecular signals in the cell itself. By artificially triggering the receptor using a synthesised product, the action of insulin can be mimicked so that further in-depth studies can take place.
The artificial interactions are carried out using a Biacore T-200, a key piece of equipment which measures the interactions between the two molecules in real time. The machine is able to spot and measure the interaction to ascertain if there is any significant kinetic data, through immobilising the receptor-like protein. Understanding how the receptor and hormone interact can provide key information in how best to treat the condition.
Thanks to our modern lifestyles and diets rich in sugar and fat, diabetes is a condition which affects millions of people across the globe. If medical research is able to eliminate the need for injectable insulin, it could greatly improve the treatment of this disease. If you’re concerned that you may be suffering from diabetes, speak to your GP who can advise whether you need to be tested, as well as offering advice should you require treatment. A balanced diet and plenty of exercise can help to lower your risk.
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